Relationship between MRI First pass Perfusion Parameters and Biventricular Performance in Pulmonary Hypertension

Background The amount of blood flow through the lungs is determined by pulmonary by pressure gradient as well as cardiac function in PH. Dynamic contrast-enhanced MRI (DCE-MRI) enables high temporal resolution imaging to track the first transit of contrast material bolus through the pulmonary circulation. First-pass parameters such as pulmonary transit time (PTT), left ventricular (LV) full width at half maximum (FWHM), and LV time to peak (TTP) have been shown to be impaired in PAH compared to controls. Little has been reported regarding the relationship between first pass perfusion parameters in other groups of PH. Our aim was to explore the relationship between first-pass parameters and RV and LV performance in patients with group I (PAH) and group IV (chronic thromboembolic pulmonary hypertension) PH